5LN2

Discovery of a novel class of highly potent inhibitors of the p53-MDM2 interaction by structure-based design starting from a conformational argument

Summary for 5LN2

Entry DOI	10.2210/pdb5ln2/pdb
Descriptor	E3 ubiquitin-protein ligase Mdm2, (4~{S})-5-[5-chloranyl-2-[2-(dimethylamino)ethoxy]phenyl]-4-(4-chloranyl-2-methyl-phenyl)-2-(2-methoxyphenyl)-3-propan-2-yl-4~{H}-pyrrolo[3,4-c]pyrazol-6-one, SULFATE ION, ... (5 entities in total)
Functional Keywords	ppi with p53, inhibitor complex, cell cycle
Biological source	Homo sapiens (Human)
Cellular location	Nucleus, nucleoplasm: Q00987
Total number of polymer chains	1
Total formula weight	11881.11
Authors	Kallen, J. (deposition date: 2016-08-02, release date: 2016-09-07, Last modification date: 2024-01-10)
Primary citation	Furet, P.,Masuya, K.,Kallen, J.,Stachyra-Valat, T.,Ruetz, S.,Guagnano, V.,Holzer, P.,Mah, R.,Stutz, S.,Vaupel, A.,Chene, P.,Jeay, S.,Schlapbach, A. Discovery of a novel class of highly potent inhibitors of the p53-MDM2 interaction by structure-based design starting from a conformational argument. Bioorg.Med.Chem.Lett., 26:4837-4841, 2016 Cited by PubMed: 27542305 DOI: 10.1016/j.bmcl.2016.08.010 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.58 Å)

Structure validation