5LN2

Discovery of a novel class of highly potent inhibitors of the p53-MDM2 interaction by structure-based design starting from a conformational argument

5LN2 の概要

• エントリーDOI: 10.2210/pdb5ln2/pdb
• 分子名称: E3 ubiquitin-protein ligase Mdm2, (4~{S})-5-[5-chloranyl-2-[2-(dimethylamino)ethoxy]phenyl]-4-(4-chloranyl-2-methyl-phenyl)-2-(2-methoxyphenyl)-3-propan-2-yl-4~{H}-pyrrolo[3,4-c]pyrazol-6-one, SULFATE ION, ... (5 entities in total)
• 機能のキーワード: ppi with p53, inhibitor complex, cell cycle
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Nucleus, nucleoplasm: Q00987
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 11881.11

構造登録者

Kallen, J. (登録日: 2016-08-02, 公開日: 2016-09-07, 最終更新日: 2024-01-10)

• 主引用文献: Furet, P.,Masuya, K.,Kallen, J.,Stachyra-Valat, T.,Ruetz, S.,Guagnano, V.,Holzer, P.,Mah, R.,Stutz, S.,Vaupel, A.,Chene, P.,Jeay, S.,Schlapbach, A.; Discovery of a novel class of highly potent inhibitors of the p53-MDM2 interaction by structure-based design starting from a conformational argument.; Bioorg.Med.Chem.Lett., 26:4837-4841, 2016; PubMed: 27542305; DOI: 10.1016/j.bmcl.2016.08.010

実験手法

X-RAY DIFFRACTION (1.58 Å)