5LIT
Structure of the DNA duplex d(AAATTT)2 with the potential antiparasitic drug 6XV at 1.25 A resolution
Summary for 5LIT
Entry DOI | 10.2210/pdb5lit/pdb |
Descriptor | DNA (5'-D(*AP*AP*AP*TP*TP*T)-3'), 4-((4,5-dihydro-1H-imidazol-2-yl)amino)-N-(4-((4,5-dihydro-1H-imidazol-2-yl)amino)phenyl)benzamide dihydrochloride, MAGNESIUM ION, ... (4 entities in total) |
Functional Keywords | all at dna, antiparasitic drug, minor groove binding drug, dna |
Biological source | synthetic construct |
Total number of polymer chains | 4 |
Total formula weight | 8416.43 |
Authors | Millan, C.R.,Dardonville, C.,de Koning, H.P.,Saperas, N.,Lourdes Campos, J. (deposition date: 2016-07-15, release date: 2017-06-14, Last modification date: 2024-05-08) |
Primary citation | Millan, C.R.,Acosta-Reyes, F.J.,Lagartera, L.,Ebiloma, G.U.,Lemgruber, L.,Nue Martinez, J.J.,Saperas, N.,Dardonville, C.,de Koning, H.P.,Campos, J.L. Functional and structural analysis of AT-specific minor groove binders that disrupt DNA-protein interactions and cause disintegration of the Trypanosoma brucei kinetoplast. Nucleic Acids Res., 45:8378-8391, 2017 Cited by PubMed: 28637278DOI: 10.1093/nar/gkx521 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.25 Å) |
Structure validation
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