5LHN
The catalytic domain of murine urokinase-type plasminogen activator in complex with the allosteric inhibitory nanobody Nb7
Summary for 5LHN
Entry DOI | 10.2210/pdb5lhn/pdb |
Descriptor | Urokinase-type plasminogen activator, Camelid-Derived Antibody Fragment Nb7, SULFATE ION, ... (5 entities in total) |
Functional Keywords | trypsin-like serine proteases, nanobody, inhibitor, hydrolase-antibody complex, hydrolase/antibody |
Biological source | Mus musculus (House Mouse) More |
Cellular location | Secreted: P06869 |
Total number of polymer chains | 2 |
Total formula weight | 44654.66 |
Authors | Kromann-Hansen, T.,Lange, E.L.,Sorensen, H.P.,Ghassabeh, G.H.,Huang, M.,Jensen, J.K.,Muyldermans, S.,Declerck, P.,Andreasen, P.A. (deposition date: 2016-07-12, release date: 2017-06-28, Last modification date: 2024-01-10) |
Primary citation | Kromann-Hansen, T.,Louise Lange, E.,Peter Srensen, H.,Hassanzadeh-Ghassabeh, G.,Huang, M.,Jensen, J.K.,Muyldermans, S.,Declerck, P.J.,Komives, E.A.,Andreasen, P.A. Discovery of a novel conformational equilibrium in urokinase-type plasminogen activator. Sci Rep, 7:3385-3385, 2017 Cited by PubMed: 28611361DOI: 10.1038/s41598-017-03457-7 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.55 Å) |
Structure validation
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