5LGT
Thieno[3,2-b]pyrrole-5-carboxamides as Novel Reversible Inhibitors of Histone Lysine Demethylase KDM1A/LSD1: Compound 15
Summary for 5LGT
Entry DOI | 10.2210/pdb5lgt/pdb |
Descriptor | Lysine-specific histone demethylase 1A, REST corepressor 1, FLAVIN-ADENINE DINUCLEOTIDE, ... (4 entities in total) |
Functional Keywords | oxidoreductase |
Biological source | Homo sapiens (Human) More |
Cellular location | Nucleus : O60341 Q9UKL0 |
Total number of polymer chains | 2 |
Total formula weight | 102785.41 |
Authors | Mattevi, A.,Ciossani, G. (deposition date: 2016-07-08, release date: 2017-02-22, Last modification date: 2024-01-10) |
Primary citation | Vianello, P.,Sartori, L.,Amigoni, F.,Cappa, A.,Faga, G.,Fattori, R.,Legnaghi, E.,Ciossani, G.,Mattevi, A.,Meroni, G.,Moretti, L.,Cecatiello, V.,Pasqualato, S.,Romussi, A.,Thaler, F.,Trifiro, P.,Villa, M.,Botrugno, O.A.,Dessanti, P.,Minucci, S.,Vultaggio, S.,Zagarri, E.,Varasi, M.,Mercurio, C. Thieno[3,2-b]pyrrole-5-carboxamides as New Reversible Inhibitors of Histone Lysine Demethylase KDM1A/LSD1. Part 2: Structure-Based Drug Design and Structure-Activity Relationship. J. Med. Chem., 60:1693-1715, 2017 Cited by PubMed: 28186757DOI: 10.1021/acs.jmedchem.6b01019 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3 Å) |
Structure validation
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