5LGE

Crystal Structure of human IDH1 mutant (R132H) in complex with NADP+ and an Inhibitor related to BAY 1436032

5LGE の概要

• エントリーDOI: 10.2210/pdb5lge/pdb
• 分子名称: Isocitrate dehydrogenase [NADP] cytoplasmic, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 1,2-ETHANEDIOL, ... (6 entities in total)
• 機能のキーワード: idh1, allosteric inhibitor, nadp+, oxidoreductase
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cytoplasm : O75874
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 196600.72

構造登録者

Hillig, R.C.,Hars, U.,Korndoerfer, I.P. (登録日: 2016-07-07, 公開日: 2017-02-08, 最終更新日: 2024-01-10)

• 主引用文献: Pusch, S.,Krausert, S.,Fischer, V.,Balss, J.,Ott, M.,Schrimpf, D.,Capper, D.,Sahm, F.,Eisel, J.,Beck, A.C.,Jugold, M.,Eichwald, V.,Kaulfuss, S.,Panknin, O.,Rehwinkel, H.,Zimmermann, K.,Hillig, R.C.,Guenther, J.,Toschi, L.,Neuhaus, R.,Haegebart, A.,Hess-Stumpp, H.,Bauser, M.,Wick, W.,Unterberg, A.,Herold-Mende, C.,Platten, M.,von Deimling, A.; Pan-mutant IDH1 inhibitor BAY 1436032 for effective treatment of IDH1 mutant astrocytoma in vivo.; Acta Neuropathol., 133:629-644, 2017; PubMed: 28124097; DOI: 10.1007/s00401-017-1677-y

実験手法

X-RAY DIFFRACTION (2.7 Å)