5LEA

Crystal structure of DARPin-DARPin rigid fusion, variant DD_Off7_12_3G124

Summary for 5LEA

Entry DOI	10.2210/pdb5lea/pdb
Descriptor	DD_Off7_12_3G124, (4S)-2-METHYL-2,4-PENTANEDIOL (3 entities in total)
Functional Keywords	de novo protein, designed ankyrin repeat proteins, protein design, protein engineering, rigid domain fusions
Biological source	synthetic construct
Total number of polymer chains	1
Total formula weight	35502.15
Authors	Batyuk, A.,Wu, Y.,Mittl, P.R.,Plueckthun, A. (deposition date: 2016-06-29, release date: 2017-08-02, Last modification date: 2024-01-10)
Primary citation	Wu, Y.,Batyuk, A.,Honegger, A.,Brandl, F.,Mittl, P.R.E.,Pluckthun, A. Rigidly connected multispecific artificial binders with adjustable geometries. Sci Rep, 7:11217-11217, 2017 Cited by PubMed: 28894181 DOI: 10.1038/s41598-017-11472-x PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation