5LCR

Cocrystal structure of cAMP-dependent Protein Kinase (PKA) in complex with open-chain Fasudil-derivative (Ligand 04)

5LCR の概要

• エントリーDOI: 10.2210/pdb5lcr/pdb
• 関連するPDBエントリー: 5LCP 5LCQ
• 分子名称: cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase inhibitor alpha, 2-[isoquinolin-5-ylsulfonyl(propyl)amino]ethylazanium, ... (6 entities in total)
• 機能のキーワード: pka, kinase, fasudil-derivative, inhibition, cocrystal, 3x-phosphorylated, ligand 10, transferase
• 由来する生物種: Cricetulus griseus (Chinese hamster); 詳細
• 細胞内の位置: Cytoplasm : P25321
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 43912.95

構造登録者

Wienen-Schmidt, B.,Heine, A.,Klebe, G. (登録日: 2016-06-22, 公開日: 2018-01-17, 最終更新日: 2024-01-10)

• 主引用文献: Wienen, B.,Jonker, H.R.A.,Wulsdorf, T.,Gerber, H.-D.,Saxena, K.,Kudlinzki, D.,Sreeramulu, S.,Parigi, G.,Luchinat, C.,Heine, A.,Schwalbe, H.,Klebe, G.; Cocrystal structure of cAMP-dependent Protein Kinase (PKA) in complex with different Fasudil-derivatives; To Be Published,

実験手法

X-RAY DIFFRACTION (1.565 Å)