5LBQ

LSD1-CoREST1 in complex with quinazoline-derivative reversible inhibitor

Summary for 5LBQ

• Entry DOI: 10.2210/pdb5lbq/pdb
• Descriptor: Lysine-specific histone demethylase 1A, REST corepressor 1, FLAVIN-ADENINE DINUCLEOTIDE, ... (4 entities in total)
• Functional Keywords: oxidoreductase-repressor complex, lsd1, kdm1a, corest1, chromatin, epigenetic, oxidoreductase/repressor
• Biological source: Homo sapiens (Human); More
• Cellular location: Nucleus : O60341 Q9UKL0
• Total number of polymer chains: 2
• Total formula weight: 103310.10

Authors

Speranzini, V.,Rotili, D.,Ciossani, G.,Pilotto, S.,Forgione, M.,Lucidi, A.,Forneris, F.,Velankar, S.,Mai, A.,Mattevi, A. (deposition date: 2016-06-16, release date: 2016-09-21, Last modification date: 2024-01-10)

• Primary citation: Speranzini, V.,Rotili, D.,Ciossani, G.,Pilotto, S.,Marrocco, B.,Forgione, M.,Lucidi, A.,Forneris, F.,Mehdipour, P.,Velankar, S.,Mai, A.,Mattevi, A.; Polymyxins and quinazolines are LSD1/KDM1A inhibitors with unusual structural features.; Sci Adv, 2:e1601017-e1601017, 2016; PubMed: 27626075; DOI: 10.1126/sciadv.1601017

Experimental method

X-RAY DIFFRACTION (3.3 Å)