5LBH

Crystal structure of Helicobacter cinaedi CAIP

Summary for 5LBH

• Entry DOI: 10.2210/pdb5lbh/pdb
• Descriptor: CAIP, FE (III) ION (3 entities in total)
• Functional Keywords: dps-like protein neutrophile activating protein mini-ferritin, transport protein
• Biological source: Helicobacter cinaedi
• Total number of polymer chains: 12
• Total formula weight: 198259.51

Authors

Zanotti, G.,Valesse, F.,Codolo, G.,De Bernard, M. (deposition date: 2016-06-16, release date: 2017-04-26, Last modification date: 2024-01-10)

Primary citation

D'Elios, M.M.,Vallese, F.,Capitani, N.,Benagiano, M.,Bernardini, M.L.,Rossi, M.,Rossi, G.P.,Ferrari, M.,Baldari, C.T.,Zanotti, G.,de Bernard, M.,Codolo, G.
The Helicobacter cinaedi antigen CAIP participates in atherosclerotic inflammation by promoting the differentiation of macrophages in foam cells.
Sci Rep, 7:40515-40515, 2017

PubMed Abstract: Recent studies have shown that certain specific microbial infections participate in atherosclerosis by inducing inflammation and immune reactions, but how the pathogens implicated in this pathology trigger the host responses remains unknown. In this study we show that Helicobacter cinaedi (Hc) is a human pathogen linked to atherosclerosis development since at least 27% of sera from atherosclerotic patients specifically recognize a protein of the Hc proteome, that we named Cinaedi Atherosclerosis Inflammatory Protein (CAIP) (n = 71). CAIP appears to be implicated in this pathology because atheromatous plaques isolated from atherosclerotic patients are enriched in CAIP-specific T cells (10%) which, in turn, we show to drive a Th1 inflammation, an immunopathological response typically associated to atherosclerosis. Recombinant CAIP promotes the differentiation and maintenance of the pro-inflammatory profile of human macrophages and triggers the formation of foam cells, which are a hallmark of atherosclerosis. This study identifies CAIP as a relevant factor in atherosclerosis inflammation linked to Hc infection and suggests that preventing and eradicating Hc infection could reduce the incidence of atherosclerosis.

PubMed: 28074932
DOI: 10.1038/srep40515

Experimental method

X-RAY DIFFRACTION (2.553 Å)