5LBH

Crystal structure of Helicobacter cinaedi CAIP

5LBH の概要

• エントリーDOI: 10.2210/pdb5lbh/pdb
• 分子名称: CAIP, FE (III) ION (3 entities in total)
• 機能のキーワード: dps-like protein neutrophile activating protein mini-ferritin, transport protein
• 由来する生物種: Helicobacter cinaedi
• タンパク質・核酸の鎖数: 12
• 化学式量合計: 198259.51

構造登録者

Zanotti, G.,Valesse, F.,Codolo, G.,De Bernard, M. (登録日: 2016-06-16, 公開日: 2017-04-26, 最終更新日: 2024-01-10)

主引用文献

D'Elios, M.M.,Vallese, F.,Capitani, N.,Benagiano, M.,Bernardini, M.L.,Rossi, M.,Rossi, G.P.,Ferrari, M.,Baldari, C.T.,Zanotti, G.,de Bernard, M.,Codolo, G.
The Helicobacter cinaedi antigen CAIP participates in atherosclerotic inflammation by promoting the differentiation of macrophages in foam cells.
Sci Rep, 7:40515-40515, 2017

PubMed Abstract: Recent studies have shown that certain specific microbial infections participate in atherosclerosis by inducing inflammation and immune reactions, but how the pathogens implicated in this pathology trigger the host responses remains unknown. In this study we show that Helicobacter cinaedi (Hc) is a human pathogen linked to atherosclerosis development since at least 27% of sera from atherosclerotic patients specifically recognize a protein of the Hc proteome, that we named Cinaedi Atherosclerosis Inflammatory Protein (CAIP) (n = 71). CAIP appears to be implicated in this pathology because atheromatous plaques isolated from atherosclerotic patients are enriched in CAIP-specific T cells (10%) which, in turn, we show to drive a Th1 inflammation, an immunopathological response typically associated to atherosclerosis. Recombinant CAIP promotes the differentiation and maintenance of the pro-inflammatory profile of human macrophages and triggers the formation of foam cells, which are a hallmark of atherosclerosis. This study identifies CAIP as a relevant factor in atherosclerosis inflammation linked to Hc infection and suggests that preventing and eradicating Hc infection could reduce the incidence of atherosclerosis.

PubMed: 28074932
DOI: 10.1038/srep40515

実験手法

X-RAY DIFFRACTION (2.553 Å)