5LBA

Crystal structure of human RECQL5 helicase in complex with DSPL fragment(1-cyclohexyl-3-(oxolan-2-ylmethyl)urea, SGC - Diamond XChem I04-1 fragment screening.

Summary for 5LBA

• Entry DOI: 10.2210/pdb5lba/pdb
• Descriptor: ATP-dependent DNA helicase Q5, MAGNESIUM ION, ZINC ION, ... (7 entities in total)
• Functional Keywords: helicase, recq, transcription, fragment screening, structural genomics, structural genomics consortium, sgc, hydrolase, diamond i04-1 xchem"
• Biological source: Homo sapiens (Human)
• Cellular location: Isoform Beta: Nucleus, nucleoplasm . Isoform Alpha: Cytoplasm . Isoform Gamma: Cytoplasm : O94762
• Total number of polymer chains: 4
• Total formula weight: 200677.09

Authors

Newman, J.A.,Aitkenhead, H.,Talon, R.,Savitsky, P.,Krojer, T.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Gileadi, O.,Structural Genomics Consortium (SGC) (deposition date: 2016-06-15, release date: 2016-07-06, Last modification date: 2024-10-16)

• Primary citation: Newman, J.A.,Talon, R.,Aitkenhead, H.,Savitsky, P.,Krojer, T.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Gileadi, O.; Crystal structure of human RECQL5 helicase in complex with 3D fragment (1-cyclohexyl-3-(oxolan-2-ylmethyl)urea); To be published,

Experimental method

X-RAY DIFFRACTION (2.5 Å)