5LBA

Crystal structure of human RECQL5 helicase in complex with DSPL fragment(1-cyclohexyl-3-(oxolan-2-ylmethyl)urea, SGC - Diamond XChem I04-1 fragment screening.

5LBA の概要

• エントリーDOI: 10.2210/pdb5lba/pdb
• 分子名称: ATP-dependent DNA helicase Q5, MAGNESIUM ION, ZINC ION, ... (7 entities in total)
• 機能のキーワード: helicase, recq, transcription, fragment screening, structural genomics, structural genomics consortium, sgc, hydrolase, diamond i04-1 xchem"
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Isoform Beta: Nucleus, nucleoplasm . Isoform Alpha: Cytoplasm . Isoform Gamma: Cytoplasm : O94762
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 200677.09

構造登録者

Newman, J.A.,Aitkenhead, H.,Talon, R.,Savitsky, P.,Krojer, T.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Gileadi, O.,Structural Genomics Consortium (SGC) (登録日: 2016-06-15, 公開日: 2016-07-06, 最終更新日: 2024-10-16)

• 主引用文献: Newman, J.A.,Talon, R.,Aitkenhead, H.,Savitsky, P.,Krojer, T.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Gileadi, O.; Crystal structure of human RECQL5 helicase in complex with 3D fragment (1-cyclohexyl-3-(oxolan-2-ylmethyl)urea); To be published,

実験手法

X-RAY DIFFRACTION (2.5 Å)