5LB5

Crystal structure of human RECQL5 helicase in complex with ADP/Mg (tricilinc form).

5LB5 の概要

• エントリーDOI: 10.2210/pdb5lb5/pdb
• 分子名称: ATP-dependent DNA helicase Q5, ZINC ION, DIMETHYL SULFOXIDE, ... (6 entities in total)
• 機能のキーワード: helicase, recq, transcription, dna repair, structural genomics, structural genomics consortium, sgc, hydrolase
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Isoform Beta: Nucleus, nucleoplasm . Isoform Alpha: Cytoplasm . Isoform Gamma: Cytoplasm : O94762
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 200450.78

構造登録者

Newman, J.A.,Aitkenhead, H.,Savitsky, P.,Krojer, T.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Gileadi, O.,Structural Genomics Consortium (SGC) (登録日: 2016-06-15, 公開日: 2016-07-06, 最終更新日: 2024-01-10)

• 主引用文献: Newman, J.A.,Aitkenhead, H.,Savitsky, P.,Gileadi, O.; Insights into the RecQ helicase mechanism revealed by the structure of the helicase domain of human RECQL5.; Nucleic Acids Res., 45:4231-4243, 2017; PubMed: 28100692; DOI: 10.1093/nar/gkw1362

実験手法

X-RAY DIFFRACTION (2 Å)