5LAR
Crystal structure of p38 alpha MAPK14 in complex with VPC00628
Summary for 5LAR
Entry DOI | 10.2210/pdb5lar/pdb |
Descriptor | Mitogen-activated protein kinase 14, 5-azanyl-~{N}-[[4-[[(2~{S})-1-azanyl-4-cyclohexyl-1-oxidanylidene-butan-2-yl]carbamoyl]phenyl]methyl]-1-phenyl-pyrazole-4-carboxamide (3 entities in total) |
Functional Keywords | transferase, protein kinase, mapk, inhibitor complex, structural genomics, structural genomics consortium, sgc |
Biological source | Mus musculus (Mouse) |
Cellular location | Cytoplasm : P47811 |
Total number of polymer chains | 1 |
Total formula weight | 41897.82 |
Authors | Chaikuad, A.,Petersen, L.K.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2016-06-14, release date: 2016-07-06, Last modification date: 2024-01-10) |
Primary citation | Petersen, L.K.,Blakskaer, P.,Chaikuad, A.,Christensen, A.B.,Dietvorst, J.,Holmkvist, J.,Knapp, S.,Korinek, M.,Larsen, L.K.,Pedersen, A.E.,Rohm, S.,Slok, F.A.,Hansen, N.J.V. Novel p38alpha MAP kinase inhibitors identified from yoctoReactor DNA-encoded small molecule library Medchemcomm, 7:1332-1339, 2016 Cited by DOI: 10.1039/C6MD00241BPDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.5 Å) |
Structure validation
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