5LAR

Crystal structure of p38 alpha MAPK14 in complex with VPC00628

Summary for 5LAR

• Entry DOI: 10.2210/pdb5lar/pdb
• Descriptor: Mitogen-activated protein kinase 14, 5-azanyl-~{N}-[[4-[[(2~{S})-1-azanyl-4-cyclohexyl-1-oxidanylidene-butan-2-yl]carbamoyl]phenyl]methyl]-1-phenyl-pyrazole-4-carboxamide (3 entities in total)
• Functional Keywords: transferase, protein kinase, mapk, inhibitor complex, structural genomics, structural genomics consortium, sgc
• Biological source: Mus musculus (Mouse)
• Cellular location: Cytoplasm : P47811
• Total number of polymer chains: 1
• Total formula weight: 41897.82

Authors

Chaikuad, A.,Petersen, L.K.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2016-06-14, release date: 2016-07-06, Last modification date: 2024-01-10)

• Primary citation: Petersen, L.K.,Blakskaer, P.,Chaikuad, A.,Christensen, A.B.,Dietvorst, J.,Holmkvist, J.,Knapp, S.,Korinek, M.,Larsen, L.K.,Pedersen, A.E.,Rohm, S.,Slok, F.A.,Hansen, N.J.V.; Novel p38alpha MAP kinase inhibitors identified from yoctoReactor DNA-encoded small molecule library; Medchemcomm, 7:1332-1339, 2016; DOI: 10.1039/C6MD00241B

Experimental method

X-RAY DIFFRACTION (1.5 Å)