5LAP

p53 cancer mutant Y220C with Cys182 alkylation

5LAP の概要

• エントリーDOI: 10.2210/pdb5lap/pdb
• 分子名称: Cellular tumor antigen p53, ZINC ION, 5-chloranylpyrimidine-4-carboxylic acid, ... (4 entities in total)
• 機能のキーワード: p53, tumor suppressor, cancer mutation, protein stabilization, alkylating agents, 2-sulfonylpyrimidines, cancer therapy, dna binding protein
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cytoplasm. Isoform 1: Nucleus. Isoform 2: Nucleus. Isoform 3: Nucleus. Isoform 4: Nucleus. Isoform 7: Nucleus. Isoform 8: Nucleus. Isoform 9: Cytoplasm: P04637
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 49509.53

構造登録者

Joerger, A.C.,Bauer, M.R.,Fersht, A.R. (登録日: 2016-06-14, 公開日: 2016-08-10, 最終更新日: 2024-01-10)

• 主引用文献: Bauer, M.R.,Joerger, A.C.,Fersht, A.R.; 2-Sulfonylpyrimidines: Mild alkylating agents with anticancer activity toward p53-compromised cells.; Proc.Natl.Acad.Sci.USA, 113:E5271-E5280, 2016; PubMed: 27551077; DOI: 10.1073/pnas.1610421113

実験手法

X-RAY DIFFRACTION (1.42 Å)