5LA6

Tubulin-pironetin complex

Summary for 5LA6

Entry DOI	10.2210/pdb5la6/pdb
Descriptor	Tubulin alpha-1B chain, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, Tubulin beta-2B chain, ... (11 entities in total)
Functional Keywords	cell cycle, tubulin fold, cytoskeleton, microtubule
Biological source	Rattus norvegicus (Norway Rat) More
Cellular location	Cytoplasm, cytoskeleton: P81947 Q6B856 Golgi apparatus : P63043
Total number of polymer chains	6
Total formula weight	264628.99
Authors	Prota, A.E.,Setter, J.,Waight, A.B.,Bargsten, K.,Murga, J.,Diaz, J.F.,Steinmetz, M.O. (deposition date: 2016-06-13, release date: 2016-07-20, Last modification date: 2024-01-10)
Primary citation	Prota, A.E.,Setter, J.,Waight, A.B.,Bargsten, K.,Murga, J.,Diaz, J.F.,Steinmetz, M.O. Pironetin Binds Covalently to alpha Cys316 and Perturbs a Major Loop and Helix of alpha-Tubulin to Inhibit Microtubule Formation. J.Mol.Biol., 428:2981-2988, 2016 Cited by PubMed: 27395016 DOI: 10.1016/j.jmb.2016.06.023 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation