5L9Y

Crystal structure of human heparanase, in complex with glucuronic acid configured aziridine probe JJB355

5L9Y の概要

• エントリーDOI: 10.2210/pdb5l9y/pdb
• 分子名称: Heparanase, alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• 機能のキーワード: heparanase, probe, gh79, hydrolase
• 由来する生物種: Homo sapiens (Human); 詳細
• 細胞内の位置: Lysosome membrane; Peripheral membrane protein: Q9Y251 Q9Y251
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 53632.47

構造登録者

Wu, L.,Jin, Y.,Davies, G.J. (登録日: 2016-06-13, 公開日: 2017-05-31, 最終更新日: 2024-01-10)

• 主引用文献: Wu, L.,Jiang, J.,Jin, Y.,Kallemeijn, W.W.,Kuo, C.L.,Artola, M.,Dai, W.,van Elk, C.,van Eijk, M.,van der Marel, G.A.,Codee, J.D.C.,Florea, B.I.,Aerts, J.M.F.G.,Overkleeft, H.S.,Davies, G.J.; Activity-based probes for functional interrogation of retaining beta-glucuronidases.; Nat. Chem. Biol., 13:867-873, 2017; PubMed: 28581485; DOI: 10.1038/nchembio.2395

実験手法

X-RAY DIFFRACTION (1.88 Å)