5L8P
Thermolysin in complex with JC114 (PEG400 cryo protectant)
Summary for 5L8P
Entry DOI | 10.2210/pdb5l8p/pdb |
Descriptor | Thermolysin, ZINC ION, CALCIUM ION, ... (6 entities in total) |
Functional Keywords | hydrolase, metalloprotease, hydrolase inhibitor complex |
Biological source | Bacillus thermoproteolyticus |
Cellular location | Secreted: P00800 |
Total number of polymer chains | 1 |
Total formula weight | 35197.85 |
Authors | Krimmer, S.G.,Cramer, J.,Heine, A.,Klebe, G. (deposition date: 2016-06-08, release date: 2016-12-21, Last modification date: 2024-01-10) |
Primary citation | Krimmer, S.G.,Cramer, J.,Betz, M.,Fridh, V.,Karlsson, R.,Heine, A.,Klebe, G. Rational Design of Thermodynamic and Kinetic Binding Profiles by Optimizing Surface Water Networks Coating Protein-Bound Ligands. J. Med. Chem., 59:10530-10548, 2016 Cited by PubMed: 27933956DOI: 10.1021/acs.jmedchem.6b00998 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.29 Å) |
Structure validation
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