5L8D

X-ray structure of NikA from Escherichia coli in complex with Ru(bis(pyrzol-1-yl)acetate scorpionate)(CO)2Cl

Summary for 5L8D

Entry DOI	10.2210/pdb5l8d/pdb
Related	3MVW
Descriptor	Nickel-binding periplasmic protein, CARBON MONOXIDE, ACETATE ION, ... (11 entities in total)
Functional Keywords	nickel-binding protein, artificial enzymes, bio-inspired chemistry, metal binding protein
Biological source	Escherichia coli (strain K12)
Total number of polymer chains	2
Total formula weight	115281.36
Authors	Menage, S.,Cavazza, C. (deposition date: 2016-06-07, release date: 2017-03-29, Last modification date: 2024-01-10)
Primary citation	Lopez, S.,Rondot, L.,Cavazza, C.,Iannello, M.,Boeri-Erba, E.,Burzlaff, N.,Strinitz, F.,Jorge-Robin, A.,Marchi-Delapierre, C.,Menage, S. Efficient conversion of alkenes to chlorohydrins by a Ru-based artificial enzyme. Chem. Commun. (Camb.), 53:3579-3582, 2017 Cited by PubMed Abstract: Artificial enzymes are required to catalyse non-natural reactions. Here, a hybrid catalyst was developed by embedding a novel Ru complex in the transport protein NikA. The protein scaffold activates the bound Ru complex to produce a catalyst with high regio- and stereo-selectivity. The hybrid efficiently and stably produced α-hydroxy-β-chloro chlorohydrins from alkenes (up to 180 TON with a TOF of 1050 h). PubMed: 28289745 DOI: 10.1039/c6cc08873b PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation