5L8D

X-ray structure of NikA from Escherichia coli in complex with Ru(bis(pyrzol-1-yl)acetate scorpionate)(CO)2Cl

5L8D の概要

• エントリーDOI: 10.2210/pdb5l8d/pdb
• 関連するPDBエントリー: 3MVW
• 分子名称: Nickel-binding periplasmic protein, CARBON MONOXIDE, ACETATE ION, ... (11 entities in total)
• 機能のキーワード: nickel-binding protein, artificial enzymes, bio-inspired chemistry, metal binding protein
• 由来する生物種: Escherichia coli (strain K12)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 115281.36

構造登録者

Menage, S.,Cavazza, C. (登録日: 2016-06-07, 公開日: 2017-03-29, 最終更新日: 2024-01-10)

主引用文献

Lopez, S.,Rondot, L.,Cavazza, C.,Iannello, M.,Boeri-Erba, E.,Burzlaff, N.,Strinitz, F.,Jorge-Robin, A.,Marchi-Delapierre, C.,Menage, S.
Efficient conversion of alkenes to chlorohydrins by a Ru-based artificial enzyme.
Chem. Commun. (Camb.), 53:3579-3582, 2017

PubMed Abstract: Artificial enzymes are required to catalyse non-natural reactions. Here, a hybrid catalyst was developed by embedding a novel Ru complex in the transport protein NikA. The protein scaffold activates the bound Ru complex to produce a catalyst with high regio- and stereo-selectivity. The hybrid efficiently and stably produced α-hydroxy-β-chloro chlorohydrins from alkenes (up to 180 TON with a TOF of 1050 h).

PubMed: 28289745
DOI: 10.1039/c6cc08873b

実験手法

X-RAY DIFFRACTION (1.8 Å)