5L7Y

17beta-hydroxysteroid dehydrogenase 14 variant T205 in complex with a non-steroidal inhibitor.

5L7Y の概要

• エントリーDOI: 10.2210/pdb5l7y/pdb
• 分子名称: 17-beta-hydroxysteroid dehydrogenase 14, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, SODIUM ION, ... (5 entities in total)
• 機能のキーワード: hydroxysteroid dehydrogenase, inhibitor complex, oxidoreductase
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cytoplasm : Q9BPX1
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 30023.72

構造登録者

Bertoletti, N.,Braun, F.,Marchais-Oberwinkler, S.,Heine, A.,Klebe, G. (登録日: 2016-06-04, 公開日: 2016-12-21, 最終更新日: 2024-01-10)

• 主引用文献: Braun, F.,Bertoletti, N.,Moller, G.,Adamski, J.,Steinmetzer, T.,Salah, M.,Abdelsamie, A.S.,van Koppen, C.J.,Heine, A.,Klebe, G.,Marchais-Oberwinkler, S.; First Structure-Activity Relationship of 17 beta-Hydroxysteroid Dehydrogenase Type 14 Nonsteroidal Inhibitors and Crystal Structures in Complex with the Enzyme.; J. Med. Chem., 59:10719-10737, 2016; PubMed: 27933965; DOI: 10.1021/acs.jmedchem.6b01436

実験手法

X-RAY DIFFRACTION (1.912 Å)