5L3B
Human LSD1/CoREST: LSD1 D556G mutation
Summary for 5L3B
Entry DOI | 10.2210/pdb5l3b/pdb |
Descriptor | Lysine-specific histone demethylase 1A, REST corepressor 1, FLAVIN-ADENINE DINUCLEOTIDE (3 entities in total) |
Functional Keywords | oxidoreductase-repressor complex, histone demethylase, chromatin, flavin, fad, oxidoreductase/repressor |
Biological source | Homo sapiens (Human) More |
Cellular location | Nucleus : O60341 Q9UKL0 |
Total number of polymer chains | 2 |
Total formula weight | 146840.93 |
Authors | Pilotto, S.,Speranzini, V.,Marabelli, C. (deposition date: 2016-04-06, release date: 2016-05-04, Last modification date: 2024-01-10) |
Primary citation | Pilotto, S.,Speranzini, V.,Marabelli, C.,Rusconi, F.,Toffolo, E.,Grillo, B.,Battaglioli, E.,Mattevi, A. LSD1/KDM1A mutations associated to a newly described form of intellectual disability impair demethylase activity and binding to transcription factors. Hum.Mol.Genet., 25:2578-2587, 2016 Cited by PubMed: 27094131DOI: 10.1093/hmg/ddw120 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.3 Å) |
Structure validation
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