5L3B

Human LSD1/CoREST: LSD1 D556G mutation

5L3B の概要

• エントリーDOI: 10.2210/pdb5l3b/pdb
• 分子名称: Lysine-specific histone demethylase 1A, REST corepressor 1, FLAVIN-ADENINE DINUCLEOTIDE (3 entities in total)
• 機能のキーワード: oxidoreductase-repressor complex, histone demethylase, chromatin, flavin, fad, oxidoreductase/repressor
• 由来する生物種: Homo sapiens (Human); 詳細
• 細胞内の位置: Nucleus : O60341 Q9UKL0
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 146840.93

構造登録者

Pilotto, S.,Speranzini, V.,Marabelli, C. (登録日: 2016-04-06, 公開日: 2016-05-04, 最終更新日: 2024-01-10)

• 主引用文献: Pilotto, S.,Speranzini, V.,Marabelli, C.,Rusconi, F.,Toffolo, E.,Grillo, B.,Battaglioli, E.,Mattevi, A.; LSD1/KDM1A mutations associated to a newly described form of intellectual disability impair demethylase activity and binding to transcription factors.; Hum.Mol.Genet., 25:2578-2587, 2016; PubMed: 27094131; DOI: 10.1093/hmg/ddw120

実験手法

X-RAY DIFFRACTION (3.3 Å)