5KZI
Crystal structure of human Pim-1 kinase in complex with an imidazopyridazine inhibitor.
Summary for 5KZI
Entry DOI | 10.2210/pdb5kzi/pdb |
Descriptor | Serine/threonine-protein kinase pim-1, ~{N}-[4-[(3~{S})-3-azanylpiperidin-1-yl]pyridin-3-yl]-2-[2,6-bis(fluoranyl)phenyl]imidazo[1,5-b]pyridazin-7-amine (3 entities in total) |
Functional Keywords | transferase, serine/threonine protein kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Isoform 2: Cytoplasm. Isoform 1: Cell membrane: P11309 |
Total number of polymer chains | 1 |
Total formula weight | 33485.87 |
Authors | Mohr, C. (deposition date: 2016-07-25, release date: 2016-11-09, Last modification date: 2024-03-06) |
Primary citation | Wurz, R.P.,Sastri, C.,D'Amico, D.C.,Herberich, B.,Jackson, C.L.,Pettus, L.H.,Tasker, A.S.,Wu, B.,Guerrero, N.,Lipford, J.R.,Winston, J.T.,Yang, Y.,Wang, P.,Nguyen, Y.,Andrews, K.L.,Huang, X.,Lee, M.R.,Mohr, C.,Zhang, J.D.,Reid, D.L.,Xu, Y.,Zhou, Y.,Wang, H.L. Discovery of imidazopyridazines as potent Pim-1/2 kinase inhibitors. Bioorg. Med. Chem. Lett., 26:5580-5590, 2016 Cited by PubMed: 27769621DOI: 10.1016/j.bmcl.2016.09.067 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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