5KZD

N-acetylneuraminate lyase from methicillin-resistant Staphylococcus aureus with bound sialic acid alditol

Summary for 5KZD

• Entry DOI: 10.2210/pdb5kzd/pdb
• Related: 5KZE
• Descriptor: N-acetylneuraminate lyase, (2~{S},4~{S},5~{R},6~{R},7~{S},8~{R})-5-acetamido-2,4,6,7,8,9-hexakis(oxidanyl)nonanoic acid (3 entities in total)
• Functional Keywords: tim-barrel, inhibitor, n-acetylneuraminate lyase, lyase
• Biological source: Staphylococcus aureus (strain USA300)
• Cellular location: Cytoplasm : Q2FJU9
• Total number of polymer chains: 4
• Total formula weight: 133551.00

Authors

North, R.A.,Watson, A.J.A.,Pearce, F.G.,Muscroft-Taylor, A.C.,Friemann, R.,Fairbanks, A.J.,Dobson, R.C.J. (deposition date: 2016-07-25, release date: 2017-01-11, Last modification date: 2024-03-06)

• Primary citation: North, R.A.,Watson, A.J.,Pearce, F.G.,Muscroft-Taylor, A.C.,Friemann, R.,Fairbanks, A.J.,Dobson, R.C.; Structure and inhibition of N-acetylneuraminate lyase from methicillin-resistant Staphylococcus aureus.; FEBS Lett., 590:4414-4428, 2016; PubMed: 27943302; DOI: 10.1002/1873-3468.12462

Experimental method

X-RAY DIFFRACTION (2.334 Å)