5KZC

Crystal structure of an HIV-1 gp120 engineered outer domain with a Man9 glycan at position N276, in complex with broadly neutralizing antibody VRC01

5KZC の概要

• エントリーDOI: 10.2210/pdb5kzc/pdb
• 関連するPDBエントリー: 4JPJ 4JPK 5D9Q
• 分子名称: VRC01 Fab heavy chain, Engineered outer domain of gp120, VRC01 Fab light chain, ... (6 entities in total)
• 機能のキーワード: hiv, env, gp120, neutralizing antibody, n-linked glycan, immune system
• 由来する生物種: Homo sapiens; 詳細
• タンパク質・核酸の鎖数: 9
• 化学式量合計: 206912.06

構造登録者

Julien, J.-P.,Jardine, J.G.,Diwanji, D.,Schief, W.R.,Wilson, I.A. (登録日: 2016-07-24, 公開日: 2016-08-10, 最終更新日: 2023-10-04)

• 主引用文献: Jardine, J.G.,Sok, D.,Julien, J.P.,Briney, B.,Sarkar, A.,Liang, C.H.,Scherer, E.A.,Henry Dunand, C.J.,Adachi, Y.,Diwanji, D.,Hsueh, J.,Jones, M.,Kalyuzhniy, O.,Kubitz, M.,Spencer, S.,Pauthner, M.,Saye-Francisco, K.L.,Sesterhenn, F.,Wilson, P.C.,Galloway, D.M.,Stanfield, R.L.,Wilson, I.A.,Burton, D.R.,Schief, W.R.; Minimally Mutated HIV-1 Broadly Neutralizing Antibodies to Guide Reductionist Vaccine Design.; Plos Pathog., 12:e1005815-e1005815, 2016; PubMed: 27560183; DOI: 10.1371/journal.ppat.1005815

実験手法

X-RAY DIFFRACTION (3.25 Å)