5KYJ

Brain penetrant liver X receptor (LXR) modulators based on a 2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole core

5KYJ の概要

• エントリーDOI: 10.2210/pdb5kyj/pdb
• 関連するPDBエントリー: 5I4V 5KYA
• 分子名称: Oxysterols receptor LXR-beta, Retinoic acid receptor RXR-beta, (6~{R})-5-(5-fluoranyl-2-methoxy-pyrimidin-4-yl)-2-(3-methylsulfonylphenyl)-6-propan-2-yl-4,6-dihydropyrrolo[3,4-c]pyrazole, ... (4 entities in total)
• 機能のキーワード: dna binding protein, nuclear receptors, liver x receptor, retinoic acid x receptor, lxrbeta-lbd/rxrbeta-lbd heterodimer, chemical modulators
• 由来する生物種: Homo sapiens (Human); 詳細
• 細胞内の位置: Nucleus : P55055 P28702
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 122281.91

構造登録者

Chen, G.,McKeever, B.M. (登録日: 2016-07-21, 公開日: 2016-09-21, 最終更新日: 2023-10-04)

• 主引用文献: Tice, C.M.,Noto, P.B.,Fan, K.Y.,Zhao, W.,Lotesta, S.D.,Dong, C.,Marcus, A.P.,Zheng, Y.J.,Chen, G.,Wu, Z.,Van Orden, R.,Zhou, J.,Bukhtiyarov, Y.,Zhao, Y.,Lipinski, K.,Howard, L.,Guo, J.,Kandpal, G.,Meng, S.,Hardy, A.,Krosky, P.,Gregg, R.E.,Leftheris, K.,McKeever, B.M.,Singh, S.B.,Lala, D.,McGeehan, G.M.,Zhuang, L.,Claremon, D.A.; Brain penetrant liver X receptor (LXR) modulators based on a 2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole core.; Bioorg.Med.Chem.Lett., 26:5044-5050, 2016; PubMed: 27599745; DOI: 10.1016/j.bmcl.2016.08.089

実験手法

X-RAY DIFFRACTION (2.8 Å)