5KWG
Crystal structure of extracellular domain of HER2 in complex with Fcab H10-03-6
Summary for 5KWG
Entry DOI | 10.2210/pdb5kwg/pdb |
Descriptor | Receptor tyrosine-protein kinase erbB-2, Ig gamma-1 chain C region (2 entities in total) |
Functional Keywords | immune system, antibody engineering, immunoglobulin g1, fc fragment, glycosylations, ch3 domain, fcab, human epidermal growth factor receptor 2, her2/neu, erbb-2, cell surface receptor |
Biological source | Homo sapiens (Human) More |
Cellular location | Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Cytoplasm. Isoform 3: Cytoplasm: P04626 Secreted : P01857 |
Total number of polymer chains | 2 |
Total formula weight | 95278.13 |
Authors | Humm, A.,Lobner, E.,Goritzer, K.,Mlynek, G.,Obinger, C.,Djinovic-Carugo, K. (deposition date: 2016-07-18, release date: 2017-04-12, Last modification date: 2024-10-16) |
Primary citation | Lobner, E.,Humm, A.S.,Goritzer, K.,Mlynek, G.,Puchinger, M.G.,Hasenhindl, C.,Ruker, F.,Traxlmayr, M.W.,Djinovic-Carugo, K.,Obinger, C. Fcab-HER2 Interaction: a Menage a Trois. Lessons from X-Ray and Solution Studies. Structure, 25:878-889.e5, 2017 Cited by PubMed: 28528777DOI: 10.1016/j.str.2017.04.014 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (4.3 Å) |
Structure validation
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