5KWG

Crystal structure of extracellular domain of HER2 in complex with Fcab H10-03-6

Summary for 5KWG

• Entry DOI: 10.2210/pdb5kwg/pdb
• Descriptor: Receptor tyrosine-protein kinase erbB-2, Ig gamma-1 chain C region (2 entities in total)
• Functional Keywords: immune system, antibody engineering, immunoglobulin g1, fc fragment, glycosylations, ch3 domain, fcab, human epidermal growth factor receptor 2, her2/neu, erbb-2, cell surface receptor
• Biological source: Homo sapiens (Human); More
• Cellular location: Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Cytoplasm. Isoform 3: Cytoplasm: P04626; Secreted : P01857
• Total number of polymer chains: 2
• Total formula weight: 95278.13

Authors

Humm, A.,Lobner, E.,Goritzer, K.,Mlynek, G.,Obinger, C.,Djinovic-Carugo, K. (deposition date: 2016-07-18, release date: 2017-04-12, Last modification date: 2024-01-10)

• Primary citation: Lobner, E.,Humm, A.S.,Goritzer, K.,Mlynek, G.,Puchinger, M.G.,Hasenhindl, C.,Ruker, F.,Traxlmayr, M.W.,Djinovic-Carugo, K.,Obinger, C.; Fcab-HER2 Interaction: a Menage a Trois. Lessons from X-Ray and Solution Studies.; Structure, 25:878-889.e5, 2017; PubMed: 28528777; DOI: 10.1016/j.str.2017.04.014

Experimental method

X-RAY DIFFRACTION (4.3 Å)