5KWG

Crystal structure of extracellular domain of HER2 in complex with Fcab H10-03-6

5KWG の概要

• エントリーDOI: 10.2210/pdb5kwg/pdb
• 分子名称: Receptor tyrosine-protein kinase erbB-2, Ig gamma-1 chain C region (2 entities in total)
• 機能のキーワード: immune system, antibody engineering, immunoglobulin g1, fc fragment, glycosylations, ch3 domain, fcab, human epidermal growth factor receptor 2, her2/neu, erbb-2, cell surface receptor
• 由来する生物種: Homo sapiens (Human); 詳細
• 細胞内の位置: Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Cytoplasm. Isoform 3: Cytoplasm: P04626; Secreted : P01857
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 95278.13

構造登録者

Humm, A.,Lobner, E.,Goritzer, K.,Mlynek, G.,Obinger, C.,Djinovic-Carugo, K. (登録日: 2016-07-18, 公開日: 2017-04-12, 最終更新日: 2024-10-16)

• 主引用文献: Lobner, E.,Humm, A.S.,Goritzer, K.,Mlynek, G.,Puchinger, M.G.,Hasenhindl, C.,Ruker, F.,Traxlmayr, M.W.,Djinovic-Carugo, K.,Obinger, C.; Fcab-HER2 Interaction: a Menage a Trois. Lessons from X-Ray and Solution Studies.; Structure, 25:878-889.e5, 2017; PubMed: 28528777; DOI: 10.1016/j.str.2017.04.014

実験手法

X-RAY DIFFRACTION (4.3 Å)