5KW6

Two Tandem RRM Domains of PUF60 Bound to an AdML Pre-mRNA 3' Splice Site Analogue with a Modified Binding-Site Nucleic Acid Base

Summary for 5KW6

• Entry DOI: 10.2210/pdb5kw6/pdb
• Related: 5KVY 5KW1
• Descriptor: Poly(U)-binding-splicing factor PUF60, DNA (30-MER) (3 entities in total)
• Functional Keywords: tandem rrms, protein-nucleic acid complex, splicing factor, splicing-dna complex, splicing/dna
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 3
• Total formula weight: 55679.50

Authors

Crichlow, G.V.,Hsiao, H.-H.,Albright, R.,Lolis, E.J.,Braddock, D.T. (deposition date: 2016-07-15, release date: 2017-08-23, Last modification date: 2023-10-25)

• Primary citation: Hsiao, H.T.,Crichlow, G.V.,Murphy, J.W.,Folta-Stogniew, E.J.,Lolis, E.J.,Braddock, D.T.; Unraveling the mechanism of recognition of the 3' splice site of the adenovirus major late promoter intron by the alternative splicing factor PUF60.; Plos One, 15:e0242725-e0242725, 2020; PubMed: 33253191; DOI: 10.1371/journal.pone.0242725

Experimental method

X-RAY DIFFRACTION (1.91 Å)