5KW6
Two Tandem RRM Domains of PUF60 Bound to an AdML Pre-mRNA 3' Splice Site Analogue with a Modified Binding-Site Nucleic Acid Base
Summary for 5KW6
Entry DOI | 10.2210/pdb5kw6/pdb |
Related | 5KVY 5KW1 |
Descriptor | Poly(U)-binding-splicing factor PUF60, DNA (30-MER) (3 entities in total) |
Functional Keywords | tandem rrms, protein-nucleic acid complex, splicing factor, splicing-dna complex, splicing/dna |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 3 |
Total formula weight | 55679.50 |
Authors | Crichlow, G.V.,Hsiao, H.-H.,Albright, R.,Lolis, E.J.,Braddock, D.T. (deposition date: 2016-07-15, release date: 2017-08-23, Last modification date: 2023-10-25) |
Primary citation | Hsiao, H.T.,Crichlow, G.V.,Murphy, J.W.,Folta-Stogniew, E.J.,Lolis, E.J.,Braddock, D.T. Unraveling the mechanism of recognition of the 3' splice site of the adenovirus major late promoter intron by the alternative splicing factor PUF60. Plos One, 15:e0242725-e0242725, 2020 Cited by PubMed: 33253191DOI: 10.1371/journal.pone.0242725 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.91 Å) |
Structure validation
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