5KUP

Bruton's tyrosine kinase (BTK) with pyridazinone compound 9

5KUP の概要

• エントリーDOI: 10.2210/pdb5kup/pdb
• 分子名称: Tyrosine-protein kinase BTK, SULFATE ION, GLYCEROL, ... (6 entities in total)
• 機能のキーワード: protein kinase, inhibitor, non covalent, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cytoplasm: Q06187
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 32812.60

構造登録者

Eigenbrot, C.,Yu, C. (登録日: 2016-07-13, 公開日: 2016-09-14, 最終更新日: 2023-10-04)

• 主引用文献: Johnson, A.R.,Kohli, P.B.,Katewa, A.,Gogol, E.,Belmont, L.D.,Choy, R.,Penuel, E.,Burton, L.,Eigenbrot, C.,Yu, C.,Ortwine, D.F.,Bowman, K.,Franke, Y.,Tam, C.,Estevez, A.,Mortara, K.,Wu, J.,Li, H.,Lin, M.,Bergeron, P.,Crawford, J.J.,Young, W.B.; Battling Btk Mutants With Noncovalent Inhibitors That Overcome Cys481 and Thr474 Mutations.; Acs Chem.Biol., 11:2897-2907, 2016; PubMed: 27571029; DOI: 10.1021/acschembio.6b00480

実験手法

X-RAY DIFFRACTION (1.389 Å)