5KSH

Crystal structure of penicillin-binding protein 2 from Neisseria gonorrhoeae containing an A501T mutation associated with cephalosporin resistance

Summary for 5KSH

Entry DOI	10.2210/pdb5ksh/pdb
Descriptor	Penicillin-binding protein 2, GLYCEROL, SULFATE ION, ... (4 entities in total)
Functional Keywords	biosynthetic protein, class b transpeptidase, peptidoglycan synthesis
Biological source	Neisseria gonorrhoeae
Total number of polymer chains	2
Total formula weight	119478.78
Authors	Fedarovich, A.,Davies, C. (deposition date: 2016-07-08, release date: 2017-03-01, Last modification date: 2023-10-04)
Primary citation	Tomberg, J.,Fedarovich, A.,Vincent, L.R.,Jerse, A.E.,Unemo, M.,Davies, C.,Nicholas, R.A. Alanine 501 Mutations in Penicillin-Binding Protein 2 from Neisseria gonorrhoeae: Structure, Mechanism, and Effects on Cephalosporin Resistance and Biological Fitness. Biochemistry, 56:1140-1150, 2017 Cited by PubMed: 28145684 DOI: 10.1021/acs.biochem.6b01030 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation