5KSH

Crystal structure of penicillin-binding protein 2 from Neisseria gonorrhoeae containing an A501T mutation associated with cephalosporin resistance

5KSH の概要

• エントリーDOI: 10.2210/pdb5ksh/pdb
• 分子名称: Penicillin-binding protein 2, GLYCEROL, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: biosynthetic protein, class b transpeptidase, peptidoglycan synthesis
• 由来する生物種: Neisseria gonorrhoeae
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 119478.78

構造登録者

Fedarovich, A.,Davies, C. (登録日: 2016-07-08, 公開日: 2017-03-01, 最終更新日: 2023-10-04)

• 主引用文献: Tomberg, J.,Fedarovich, A.,Vincent, L.R.,Jerse, A.E.,Unemo, M.,Davies, C.,Nicholas, R.A.; Alanine 501 Mutations in Penicillin-Binding Protein 2 from Neisseria gonorrhoeae: Structure, Mechanism, and Effects on Cephalosporin Resistance and Biological Fitness.; Biochemistry, 56:1140-1150, 2017; PubMed: 28145684; DOI: 10.1021/acs.biochem.6b01030

実験手法

X-RAY DIFFRACTION (2.4 Å)