5KPQ

Structure of human PARP1 catalytic domain bound to a quinazoline-2,4(1H,3H)-dione inhibitor

Summary for 5KPQ

• Entry DOI: 10.2210/pdb5kpq/pdb
• Related: 5KPN 5KPO 5KPP
• Descriptor: Poly [ADP-ribose] polymerase 1, 1-[[4-fluoranyl-3-[(3R)-3-methyl-4-propyl-piperazin-1-yl]carbonyl-phenyl]methyl]quinazoline-2,4-dione (3 entities in total)
• Functional Keywords: inhibitor, complex, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human)
• Cellular location: Nucleus: P09874
• Total number of polymer chains: 2
• Total formula weight: 79214.61

Authors

Cao, R.,Wang, Y.L.,Zhou, J.,Huang, N.,Xu, B.L. (deposition date: 2016-07-05, release date: 2016-12-14, Last modification date: 2023-11-08)

• Primary citation: Cao, R.,Wang, Y.L.,Zhou, J.,Huang, N.,Xu, B.L.; Structure of human PARP1 catalytic domain bound to a quinazoline-2,4(1H,3H)-dione inhibitor; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.55 Å)