5KO0

Human Islet Amyloid Polypeptide Segment 15-FLVHSSNNFGA-25 Determined by MicroED

Summary for 5KO0

• Entry DOI: 10.2210/pdb5ko0/pdb
• Related: 5KNZ
• EMDB information: 8272 8273
• Descriptor: hIAPP(15-25)WT, THIOCYANATE ION (3 entities in total)
• Functional Keywords: amyloid, islet amyloid polypeptide, type ii diabetes, toxic spine, microed, protein fibril
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 2444.66

Authors

Krotee, P.A.L.,Rodriguez, J.A.,Sawaya, M.R.,Cascio, D.,Shi, D.,Nannenga, B.L.,Hattne, J.,Reyes, F.E.,Gonen, T.,Eisenberg, D.S. (deposition date: 2016-06-28, release date: 2016-12-21, Last modification date: 2024-03-06)

• Primary citation: Krotee, P.,Rodriguez, J.A.,Sawaya, M.R.,Cascio, D.,Reyes, F.E.,Shi, D.,Hattne, J.,Nannenga, B.L.,Oskarsson, M.E.,Philipp, S.,Griner, S.,Jiang, L.,Glabe, C.G.,Westermark, G.T.,Gonen, T.,Eisenberg, D.S.; Atomic structures of fibrillar segments of hIAPP suggest tightly mated beta-sheets are important for cytotoxicity.; Elife, 6:-, 2017; PubMed: 28045370; DOI: 10.7554/eLife.19273

Experimental method

ELECTRON CRYSTALLOGRAPHY (1.4 Å)