5KN5
TGFalpha/Epiregulin complex with neutralizing antibody LY3016859
Summary for 5KN5
Entry DOI | 10.2210/pdb5kn5/pdb |
Descriptor | Epiregulin Antibody LY3016859 Fab Heavy Chain, Epiregulin Antibody LY3016859 Fab Light Chain, Protransforming growth factor alpha, ... (6 entities in total) |
Functional Keywords | tgfalpha epiregulin antibody fab, immune system |
Biological source | Homo sapiens More |
Cellular location | Transforming growth factor alpha: Secreted, extracellular space. Protransforming growth factor alpha: Cell membrane; Single-pass type I membrane protein: P01135 |
Total number of polymer chains | 6 |
Total formula weight | 103360.96 |
Authors | Atwell, S.,Boyles, J.S.,Clawson, D.K.,Druzina, Z.,Josef, G.H.,Weichert, K.,Witcher, D.R. (deposition date: 2016-06-27, release date: 2016-08-31, Last modification date: 2016-11-02) |
Primary citation | Boyles, J.S.,Atwell, S.,Druzina, Z.,Heuer, J.G.,Witcher, D.R. Structural basis of selectivity and neutralizing activity of a TGF alpha /epiregulin specific antibody. Protein Sci., 25:2028-2036, 2016 Cited by PubMed: 27543934DOI: 10.1002/pro.3023 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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