5KN5

TGFalpha/Epiregulin complex with neutralizing antibody LY3016859

5KN5 の概要

• エントリーDOI: 10.2210/pdb5kn5/pdb
• 分子名称: Epiregulin Antibody LY3016859 Fab Heavy Chain, Epiregulin Antibody LY3016859 Fab Light Chain, Protransforming growth factor alpha, ... (6 entities in total)
• 機能のキーワード: tgfalpha epiregulin antibody fab, immune system
• 由来する生物種: Homo sapiens; 詳細
• 細胞内の位置: Transforming growth factor alpha: Secreted, extracellular space. Protransforming growth factor alpha: Cell membrane; Single-pass type I membrane protein: P01135
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 103360.96

構造登録者

Atwell, S.,Boyles, J.S.,Clawson, D.K.,Druzina, Z.,Josef, G.H.,Weichert, K.,Witcher, D.R. (登録日: 2016-06-27, 公開日: 2016-08-31, 最終更新日: 2016-11-02)

• 主引用文献: Boyles, J.S.,Atwell, S.,Druzina, Z.,Heuer, J.G.,Witcher, D.R.; Structural basis of selectivity and neutralizing activity of a TGF alpha /epiregulin specific antibody.; Protein Sci., 25:2028-2036, 2016; PubMed: 27543934; DOI: 10.1002/pro.3023

実験手法

X-RAY DIFFRACTION (2.8 Å)