5KLO

Crystal structure of thioacyl intermediate in 2-aminomuconate 6-semialdehyde dehydrogenase N169A

Summary for 5KLO

• Entry DOI: 10.2210/pdb5klo/pdb
• Related: 5KLK 5KLL 5KLM 5KLN
• Descriptor: 2-aminomuconate 6-semialdehyde dehydrogenase, (2Z,4E)-2-hydroxy-6-oxohexa-2,4-dienoic acid, SODIUM ION, ... (5 entities in total)
• Functional Keywords: 2-aminomuconate 6-semialdehyde dehydrogenase, kynurenine pathway, oxidoreductase
• Biological source: Pseudomonas fluorescens
• Total number of polymer chains: 4
• Total formula weight: 227730.18

Authors

Yang, Y.,Davis, I.,Ha, U.,Wang, Y.,Shin, I.,Liu, A. (deposition date: 2016-06-24, release date: 2016-11-09, Last modification date: 2023-09-27)

• Primary citation: Yang, Y.,Davis, I.,Ha, U.,Wang, Y.,Shin, I.,Liu, A.; A Pitcher-and-Catcher Mechanism Drives Endogenous Substrate Isomerization by a Dehydrogenase in Kynurenine Metabolism.; J.Biol.Chem., 291:26252-26261, 2016; PubMed: 27810899; DOI: 10.1074/jbc.M116.759712

Experimental method

X-RAY DIFFRACTION (1.79 Å)