5KIC

Long-sought stabilization of berkelium(IV) in solution: An anomaly within the heavy actinide series

Summary for 5KIC

• Entry DOI: 10.2210/pdb5kic/pdb
• Related: 5KHP 5KID
• Descriptor: Neutrophil gelatinase-associated lipocalin, CALIFORNIUM ION, N,N'-butane-1,4-diylbis[1-hydroxy-N-(3-{[(1-hydroxy-6-oxo-1,6-dihydropyridin-2-yl)carbonyl]amino}propyl)-6-oxo-1,6-dihydropyridine-2-carboxamide], ... (6 entities in total)
• Functional Keywords: siderophore-binding, ngal, transport protein
• Biological source: Homo sapiens (Human)
• Cellular location: Secreted : P80188
• Total number of polymer chains: 3
• Total formula weight: 65501.38

Authors

Rupert, P.B.,Strong, R.K. (deposition date: 2016-06-16, release date: 2017-04-26, Last modification date: 2024-10-23)

Primary citation

Deblonde, G.J.,Sturzbecher-Hoehne, M.,Rupert, P.B.,An, D.D.,Illy, M.C.,Ralston, C.Y.,Brabec, J.,de Jong, W.A.,Strong, R.K.,Abergel, R.J.
Chelation and stabilization of berkelium in oxidation state +IV.
Nat Chem, 9:843-849, 2017

PubMed Abstract: Berkelium (Bk) has been predicted to be the only transplutonium element able to exhibit both +III and +IV oxidation states in solution, but evidence of a stable oxidized Bk chelate has so far remained elusive. Here we describe the stabilization of the heaviest 4+ ion of the periodic table, under mild aqueous conditions, using a siderophore derivative. The resulting Bk(IV) complex exhibits luminescence via sensitization through an intramolecular antenna effect. This neutral Bk(IV) coordination compound is not sequestered by the protein siderocalin-a mammalian metal transporter-in contrast to the negatively charged species obtained with neighbouring trivalent actinides americium, curium and californium (Cf). The corresponding Cf(III)-ligand-protein ternary adduct was characterized by X-ray diffraction analysis. Combined with theoretical predictions, these data add significant insight to the field of transplutonium chemistry, and may lead to innovative Bk separation and purification processes.

PubMed: 28837177
DOI: 10.1038/nchem.2759

Experimental method

X-RAY DIFFRACTION (2.7 Å)