5KHX

Crystal structure of JAK1 in complex with PF-4950736

Summary for 5KHX

Entry DOI	10.2210/pdb5khx/pdb
Descriptor	Tyrosine-protein kinase JAK1, ~{N}-[3-[methyl(7~{H}-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl]methanesulfonamide (3 entities in total)
Functional Keywords	jak1, kinase, inhibitor, complex, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (Human)
Cellular location	Endomembrane system; Peripheral membrane protein: P23458
Total number of polymer chains	1
Total formula weight	36712.83
Authors	Han, S.,Caspers, N.L. (deposition date: 2016-06-16, release date: 2016-11-09, Last modification date: 2018-05-16)
Primary citation	Caspers, N.L.,Han, S.,Rajamohan, F.,Hoth, L.R.,Geoghegan, K.F.,Subashi, T.A.,Vazquez, M.L.,Kaila, N.,Cronin, C.N.,Johnson, E.,Kurumbail, R.G. Development of a high-throughput crystal structure-determination platform for JAK1 using a novel metal-chelator soaking system. Acta Crystallogr F Struct Biol Commun, 72:840-845, 2016 Cited by PubMed: 27827355 DOI: 10.1107/S2053230X16016356 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation