5K89

Crystal Structure of Human Calcium-Bound S100A1

5K89 の概要

• エントリーDOI: 10.2210/pdb5k89/pdb
• 分子名称: Protein S100-A1, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CALCIUM ION, ... (4 entities in total)
• 機能のキーワード: s100, s100a1, calcium, metal binding protein
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 32032.96

構造登録者

Melville, Z.,Aligholizadeh, E.,McKnight, L.E.,Weber, D.,Pozharski, E.,Weber, D.J. (登録日: 2016-05-27, 公開日: 2017-04-12, 最終更新日: 2023-09-27)

主引用文献

Melville, Z.,Aligholizadeh, E.,McKnight, L.E.,Weber, D.J.,Pozharski, E.,Weber, D.J.
X-ray crystal structure of human calcium-bound S100A1.
Acta Crystallogr F Struct Biol Commun, 73:215-221, 2017

PubMed Abstract: S100A1 is a member of the S100 family of Ca-binding proteins and regulates several cellular processes, including those involved in Ca signaling and cardiac and skeletal muscle function. In Alzheimer's disease, brain S100A1 is overexpressed and gives rise to disease pathologies, making it a potential therapeutic target. The 2.25 Å resolution crystal structure of Ca-S100A1 is solved here and is compared with the structures of other S100 proteins, most notably S100B, which is a highly homologous S100-family member that is implicated in the progression of malignant melanoma. The observed structural differences in S100A1 versus S100B provide insights regarding target protein-binding specificity and for targeting these two S100 proteins in human diseases using structure-based drug-design approaches.

PubMed: 28368280
DOI: 10.1107/S2053230X17003983

実験手法

X-RAY DIFFRACTION (2.249 Å)