5K7N
MicroED structure of tau VQIVYK peptide at 1.1 A resolution
Summary for 5K7N
| Entry DOI | 10.2210/pdb5k7n/pdb |
| Related | 5K7O 5K7P 5K7Q 5K7R 5K7S 5K7T |
| EMDB information | 8216 8217 8218 8219 8220 8221 8222 |
| Descriptor | VQIVYK (2 entities in total) |
| Functional Keywords | amyloid, protein fibril |
| Biological source | Homo sapiens (human) |
| Total number of polymer chains | 1 |
| Total formula weight | 749.92 |
| Authors | de la Cruz, M.J.,Hattne, J.,Shi, D.,Seidler, P.,Rodriguez, J.,Reyes, F.E.,Sawaya, M.R.,Cascio, D.,Eisenberg, D.,Gonen, T. (deposition date: 2016-05-26, release date: 2017-04-05, Last modification date: 2024-02-28) |
| Primary citation | de la Cruz, M.J.,Hattne, J.,Shi, D.,Seidler, P.,Rodriguez, J.,Reyes, F.E.,Sawaya, M.R.,Cascio, D.,Weiss, S.C.,Kim, S.K.,Hinck, C.S.,Hinck, A.P.,Calero, G.,Eisenberg, D.,Gonen, T. Atomic-resolution structures from fragmented protein crystals with the cryoEM method MicroED. Nat. Methods, 14:399-402, 2017 Cited by PubMed Abstract: Traditionally, crystallographic analysis of macromolecules has depended on large, well-ordered crystals, which often require significant effort to obtain. Even sizable crystals sometimes suffer from pathologies that render them inappropriate for high-resolution structure determination. Here we show that fragmentation of large, imperfect crystals into microcrystals or nanocrystals can provide a simple path for high-resolution structure determination by the cryoEM method MicroED and potentially by serial femtosecond crystallography. PubMed: 28192420DOI: 10.1038/nmeth.4178 PDB entries with the same primary citation |
| Experimental method | ELECTRON CRYSTALLOGRAPHY (1.1 Å) |
Structure validation
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