5K7I
IRAK4 in complex with AZ3864
Summary for 5K7I
Entry DOI | 10.2210/pdb5k7i/pdb |
Related | 5K72 5K75 5K76 5K7G |
Descriptor | Interleukin-1 receptor-associated kinase 4, (3~{a}~{R},7~{a}~{S})-1-methyl-5-[4-[[5-(oxan-4-yl)-7~{H}-pyrrolo[2,3-d]pyrimidin-4-yl]amino]cyclohexyl]-3,3~{a},4,6,7,7~{a}-hexahydropyrrolo[3,2-c]pyridin-2-one, SULFATE ION, ... (4 entities in total) |
Functional Keywords | inhibitor, kinase, protein tyrosine kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm : Q9NWZ3 |
Total number of polymer chains | 2 |
Total formula weight | 68753.68 |
Authors | Ferguson, A.D. (deposition date: 2016-05-26, release date: 2017-12-06, Last modification date: 2023-09-27) |
Primary citation | Scott, J.S.,Degorce, S.L.,Anjum, R.,Culshaw, J.,Davies, R.D.M.,Davies, N.L.,Dillman, K.S.,Dowling, J.E.,Drew, L.,Ferguson, A.D.,Groombridge, S.D.,Halsall, C.T.,Hudson, J.A.,Lamont, S.,Lindsay, N.A.,Marden, S.K.,Mayo, M.F.,Pease, J.E.,Perkins, D.R.,Pink, J.H.,Robb, G.R.,Rosen, A.,Shen, M.,McWhirter, C.,Wu, D. Discovery and Optimization of Pyrrolopyrimidine Inhibitors of Interleukin-1 Receptor Associated Kinase 4 (IRAK4) for the Treatment of Mutant MYD88L265P Diffuse Large B-Cell Lymphoma. J. Med. Chem., 60:10071-10091, 2017 Cited by PubMed: 29172502DOI: 10.1021/acs.jmedchem.7b01290 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.31 Å) |
Structure validation
Download full validation report