5K69

Crystal structure of Mycobacterium tuberculosis L,D-transpeptidase 2 with carbapenem drug T224

5K69 の概要

• エントリーDOI: 10.2210/pdb5k69/pdb
• 分子名称: L,D-transpeptidase 2, GLYCEROL, (2~{S},3~{R},4~{R})-4-(1~{H}-indol-3-ylsulfanyl)-3-methyl-2-[(2~{S},3~{S})-3-oxidanyl-1-oxidanylidene-butan-2-yl]-3,4-dihydro-2~{H}-pyrrole-5-carboxylic acid, ... (4 entities in total)
• 機能のキーワード: peptidase, igd_like domain, ykud domain, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 87812.56

構造登録者

Lamichhane, G.,Ginell, S.L.,Kumar, P. (登録日: 2016-05-24, 公開日: 2016-11-09, 最終更新日: 2023-09-27)

• 主引用文献: Kumar, P.,Kaushik, A.,Lloyd, E.P.,Li, S.G.,Mattoo, R.,Ammerman, N.C.,Bell, D.T.,Perryman, A.L.,Zandi, T.A.,Ekins, S.,Ginell, S.L.,Townsend, C.A.,Freundlich, J.S.,Lamichhane, G.; Non-classical transpeptidases yield insight into new antibacterials.; Nat. Chem. Biol., 13:54-61, 2017; PubMed: 27820797; DOI: 10.1038/nchembio.2237

実験手法

X-RAY DIFFRACTION (2.001 Å)