5K47

CryoEM structure of the human Polycystin-2/PKD2 TRP channel

Summary for 5K47

• Entry DOI: 10.2210/pdb5k47/pdb
• EMDB information: 8200
• Descriptor: Polycystin-2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose (3 entities in total)
• Functional Keywords: ion channel, transient receptor potential channel, polycystic kidney disease, structural genomics, structural genomics consortium, sgc, transport protein
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 4
• Total formula weight: 259413.94

Authors

Pike, A.C.W.,Grieben, M.,Shintre, C.A.,Tessitore, A.,Shrestha, L.,Mukhopadhyay, S.,Mahajan, P.,Chalk, R.,Burgess-Brown, N.A.,Huiskonen, J.T.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Carpenter, E.P.,Structural Genomics Consortium (SGC) (deposition date: 2016-05-20, release date: 2016-08-24, Last modification date: 2020-10-21)

• Primary citation: Grieben, M.,Pike, A.C.,Shintre, C.A.,Venturi, E.,El-Ajouz, S.,Tessitore, A.,Shrestha, L.,Mukhopadhyay, S.,Mahajan, P.,Chalk, R.,Burgess-Brown, N.A.,Sitsapesan, R.,Huiskonen, J.T.,Carpenter, E.P.; Structure of the polycystic kidney disease TRP channel Polycystin-2 (PC2).; Nat. Struct. Mol. Biol., 24:114-122, 2017; PubMed: 27991905; DOI: 10.1038/nsmb.3343

Experimental method

ELECTRON MICROSCOPY (4.2 Å)