5K27

Crystal structure of ancestral protein ancMT of ADP-dependent sugar kinases family.

Summary for 5K27

• Entry DOI: 10.2210/pdb5k27/pdb
• Descriptor: ancMT, ADENOSINE MONOPHOSPHATE, IODIDE ION, ... (4 entities in total)
• Functional Keywords: ancestral protein reconstruction, adp-dependent sugar kinases family, glucokinase, phosphofructokinase, bifuncional enzymes, enzyme evolution, transferase
• Biological source: synthetic construct
• Total number of polymer chains: 2
• Total formula weight: 109955.36

Authors

Castro-Fernandez, V.,Herrera-Morande, A.,Zamora, R.,Merino, F.,Pereira, H.M.,Brandao-Neto, J.,Garratt, R.,Guixe, V. (deposition date: 2016-05-18, release date: 2017-05-24, Last modification date: 2023-09-27)

• Primary citation: Castro-Fernandez, V.,Herrera-Morande, A.,Zamora, R.,Merino, F.,Gonzalez-Ordenes, F.,Padilla-Salinas, F.,Pereira, H.M.,Brandao-Neto, J.,Garratt, R.C.,Guixe, V.; Reconstructed ancestral enzymes reveal that negative selection drove the evolution of substrate specificity in ADP-dependent kinases.; J. Biol. Chem., 292:21218-21218, 2017; PubMed: 29273585; DOI: 10.1074/jbc.AAC117.001147

Experimental method

X-RAY DIFFRACTION (2.58 Å)