5K1F

Crystal structure of a class C beta lactamase/compound2 complex

5K1F の概要

• エントリーDOI: 10.2210/pdb5k1f/pdb
• 関連するPDBエントリー: 5K1D
• 分子名称: Beta-lactamase, INOSINIC ACID, CADMIUM ION, ... (4 entities in total)
• 機能のキーワード: class c beta-lactamase, hydrolase
• 由来する生物種: Enterobacter aerogenes
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 40213.76

構造登録者

An, Y.J.,Na, J.H.,Cha, S.S. (登録日: 2016-05-18, 公開日: 2017-05-17, 最終更新日: 2023-11-08)

主引用文献

Na, J.H.,An, Y.J.,Cha, S.S.
GMP and IMP Are Competitive Inhibitors of CMY-10, an Extended-Spectrum Class C beta-Lactamase.
Antimicrob. Agents Chemother., 61:-, 2017

PubMed Abstract: Nucleotides were effective in inhibiting the class C β-lactamase CMY-10. IMP was the most potent competitive inhibitor, with a value of 16.2 μM. The crystal structure of CMY-10 complexed with GMP or IMP revealed that nucleotides fit into the R2 subsite of the active site with a unique vertical binding mode where the phosphate group at one terminus is deeply bound in the subsite and the base at the other terminus faces the solvent.

PubMed: 28242658
DOI: 10.1128/AAC.00098-17

実験手法

X-RAY DIFFRACTION (1.94 Å)